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The limited success of immunotherapy in solid tumors arises from several key challenges: The immunosuppressive and hypoxic TME impairs T cell proliferation, differentiation, and effector functions

Nevertheless, they activate biochemical cascades that lead to modifications of other proteins

The expression levels of phosphorylated Janus kinase 2 (pJAK2) and phosphorylated signal transducer and activator of transcription 3 (pSTAT3) are elevated in liver tissue [117]

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Metso S, Hyyti-Ilmonen H, Kaukinen K, Huhtala H, Jaatinen P, Salmi J et al (2012) Gluten-free diet and autoimmune thyroiditis in patients with celiac disease